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The feasibility of this route is determined by both the physicochemical properties of the drug and the therapeutic requirements (acute vs.long-term effect). Speed of absorption is determined by the route and method of application. It is fastest with intravenous injection, less fast which intramuscular injection, and slowest with subcutaneous injection.
Compared with whole blood or plasma, plasma substitutes offer several advantages: they can be produced more easily and at lower cost, have a longer shelf life, and are free of pathogens such as hepatitis B or C or AIDS viruses. Three colloids are currently employed as plasma volume expanders— the two polysaccharides, dextran and hydroxyethyl starch, as well as the polypeptide, gelatin.


Therapeutic agents fall into two groups: Thymoleptics, possessing a pronounced ability to re-elevate depressed mood e. g. , the tricyclic antidepressants; Thymeretics, having a predominant activating effect on psychomotor drive, e g. , monoamine oxidase inhibitors. It would be wrong to administer drive-enhancing drugs, such as amphetamines, to a patient with endogenous depression.
Any change in eating and living habits can upset control of blood sugar: skipping a meal or unusual physical stress leads to hypoglycemia; increased CH intake provokes hyperglycemia. Hypoglycemia is heralded by warning signs: tachycardia, unrest, tremor, pallor, profuse sweating. Some of these are due to the release of glucose- mobilizing epinephrine.


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